In medical research and clinical practices, there is an increasing interest in instruments used to measure health-related quality of life in general population surveys. The 12-item Short Form Health Survey (SF-12) is one of the most widely used screening device for measuring physical, mental and social well-being to assess social heterogeneity in self-reported health status. This book examines the psychometric properties of the Tunisian version of SF-12 in terms of the measurement and conceptual model, sensitivity, "known groups" construct validity, convergent validity and, hence, to increase confidence in using the SF-12 in Tunisian studies as an alternative to the more time-demanding SF-36.