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L-carnitine and CoQ10 role in combating deteriorative effect of CCL4

Sanaa Ahmed Ali

  • Categorie: Wetenschap & Natuur
  • EAN: 9783659165511
ß-Hydroxy-¿-Trimethylammonium Butyrate and Ubiquinone in combating the deteriorative effect induced by CCl4 in rat
Inhoud
Taal:en
Bindwijze:Paperback
Oorspronkelijke releasedatum:07 juli 2012
Aantal pagina's:260
Illustraties:Nee
Betrokkenen
Hoofdauteur:Sanaa Ahmed Ali
Tweede Auteur:Lilla M Faddah
Co Auteur:Bayoumi, Asmaa
Hoofduitgeverij:Lap Lambert Academic Publishing
Overige kenmerken
Extra groot lettertype:Nee
Product breedte:152 mm
Product hoogte:15 mm
Product lengte:229 mm
Studieboek:Ja
Verpakking breedte:152 mm
Verpakking hoogte:16 mm
Verpakking lengte:229 mm
Verpakkingsgewicht:386 g


Productbeschrijving

Liver cirrhosis is one of the most dangerous health problems which result from various disorders that damage liver cells over time. The purpose of this work is to evaluate the prophylactic effect of L-carnitine, coenzyme Q10 (CoQ10) or their combination against the deteriorative effect induced by carbon tetrachloride (CCl4) on rat's liver. Administration of CCl4 provides a suitable animal model for free radical damage in liver such as fatty degeneration, fibrosis, hepatocellular death and carcinogenicity. The study was carried out on rats as follows: four normal groups (control, treated with L-carnitine, treated with CoQ10, and treated with combination of L-carnitine and CoQ10) and four cirrhotic groups treated with CCl4 (control, treated with L-carnitine, treated with CoQ10, and treated with combination of L-carnitine and CoQ10). Effect of L-carnitine and CoQ10 as protective agents against liver cirrhosis was determined by measuring hepatic content of reduced glutathione, lipid peroxides, ascorbic acid, total protein and lactate dehydrogenase. Also, serum activities of alanine aminotransferase, aspartate aminotransferase, total protein, albumin, sialic acid, nitrite and lactat